George Griffin was born in 1943 in Atlanta, Georgia. He studied political science as an undergraduate at Dartmouth where he created a cartoon strip for a university literary magazine. In 1968, Griffin began to pursue a full time career in animation. Studying the works of filmmakers Stan Brakhage and Robert Breer as his guiding influences, he developed experimental animation techniques that placed him at the forefront of the 1970s avant-garde movement.

Griffin's irreverent and self-referential animations feature series of vignettes that combine drawing, film, and photography. Griffin's work has been shown at museums such as the Kunsthalle Düsseldorf and The Museum of Modern Art. His films have also been shown at international film festivals such as the Tribeca Film Festival, New York; the Cannes Film Festi-val; and the Strasbourg International Film Festival.